منابع مشابه
Prevention of colitis-associated colorectal cancer with 8-hydroxydeoxyguanosine.
Colitis-associated cancer (CAC) is one of clear examples of inflammation-carcinogenesis sequence, by which the strict control of colitis with potent anti-inflammatory or antioxidative agent offers the chance of cancer prevention. Supported with the facts that Rac1 binds and activates STAT3, which are significantly upregulated in inflammatory bowel disease (IBD) as well as CAC, but 8-hydroxydeox...
متن کاملNMR studies of a DNA containing 8-hydroxydeoxyguanosine.
The effects of hydroxylation at the C8 of a deoxyguanosine residue in DNA were studied by NMR analysis of a self-complementary dodecanucleotide, d(C1-G2-C3-oh8G4-A5-A6-T7-T8-C9-G10-C11-G12), which has an 8-hydroxy-2'-deoxyguanosine (oh8dG) residue at the 4th position. NMR data indicate that the 8-hydroxyguanine (oh8G) base takes a 6,8-diketo tautomeric form and is base-paired to C with Watson-C...
متن کاملOxidative stress in pterygium: relationship between p53 and 8-hydroxydeoxyguanosine.
PURPOSE Ultraviolet (UV) radiation is known to cause oxidative DNA damage and is thought to be a major factor implicated in the pathogenesis of pterygium, a benign invasive lesion of the bulbar conjunctiva. Among all the photooxidative DNA products, 8-hydroxydeoxyguanosine (8-OHdG) is regarded as a sensitive and stable biomarker for evaluating the degree of DNA damage. The protein p53 is a majo...
متن کاملUrinary 8-hydroxydeoxyguanosine levels in diabetic retinopathy patients.
PURPOSE Involvement of oxidative stress in the pathogenesis of diabetic microvascular complications has been proposed. Recently, 8-hydroxy-2'-deoxyguanosine (8-OHdG) has been reported to serve as a new sensitive biomarker of the oxidative DNA damage in vivo. This study was undertaken to investigate whether the urinary levels of 8-OHdG are altered in patients with type 2 diabetes. The authors al...
متن کاملDetection of Streptococcus anginosus and 8-hydroxydeoxyguanosine in saliva.
Several studies have demonstrated a close association between Streptococcus (S.) anginosus infection and head and neck cancer. Accumulation of 8-hydroxy-deoxyguanosine (8-OHdG), which may result from the continuous generation of reactive oxygen species associated with chronic inflammation, has been reported in human preneoplastic lesions and in cancerous tissues. The purpose of the present inve...
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ژورنال
عنوان ژورنال: FEBS Letters
سال: 1994
ISSN: 0014-5793
DOI: 10.1016/0014-5793(94)00583-4